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Tasigna 150mg (Nilotinib) capsules| Apple pharmaceuticals

Tasigna 150mg

          Tasigna 150mg is cancer drugs, the main ingredient which is used as lapatinib, which prohibits growth of the tumor cells. Nilotinib is sold under the brand name Tasigna which is a targeted cancer medication Tasigna tablet belongs to the class of kinase inhibitors. The medicine Tasigna in children younger than 1 year has no safety and efficacy not been established The drug Tasigna 150mg is a prescription drugs, which is used under the knowledge of medical oncologist.

DOSAGE

          The usual dose of Tasigna 150mg Tablet should be given as twice daily at 12 hours time intervals Tasigna must be administer on an empty stomach Taking of food should not be at least 1 hour after the dose is taken or 2 hours before the dose is taken Who are unable to taken the Tasigna capsules, the patients can be dispersed the tablet in one teaspoon of applesauce. This tablet should be administer immediately within 15 minutes Tasignashould be combination with hematopoietic growth factors such as erythropoietin or G-CSF Also concomitant use with hydroxyurea or anagrelide

Dosage in adult patients with Philadelphia positive CML-CP :

          The regular dose of the Tasigna 150mg tablet in this condition given is 300mg should be given orally as twice daily.

With resistant or intolerant Philadelphia positive CML-CP and CML-AP:

          The normal dose is 400mg should be administered as orally twice in a day.

In pediatrics:

         The normal dose 230mg/m2 should be administer orally twice daily The maximum dose of Tablet Tasigna is 400mg.

PHARMACOKINETICS

Absorption:   The Tasigna 150mg has bioavailability about 50% The time of peak plasma                                          concentration is occurred within 3 hours after administration.
Distribution:  The Tasigna has serum protein binding is approximately 98% The Nilotinib blood to                             serum ratio is 0.68
Metabolism:  Tasigna is metabolized via CYP3A4 mediated oxidation. The prime flowing                                          component  in the blood stream is Nilotinib.
Elimination:  The half life period of Tasigna Tablet is approximately 17 hours. The mean apparent                             clearance value is 29L/hr.
Effect of food: The effect of drug is increased to 82% when the dose was given 30 minutes after a                              high fat meal when compared to fasted patient.

MECHANISM OF ACTION

           CML: chronic myelogenous leukemia is caused by BCR-ABL oncogene.Tasigna 150mg (Nilotinib mechanism of action ) is a kinase inhibitor, which prohibits BCR-ABL kinase activity. Binding of Tasigna to the ATP-binding site of BCR-ABL protein. The drug Tasigna prevents the proliferation of murine leukemic cell lines and human cell lines derived from patients with Philadelphia positive CML

tasigna 150mg
tasigna 150mg

PRECAUTIONS

           Tasigna may cause thrombocytopenia, neutropenia and anemia, so check blood counts periodically to reduce these complications 

Embryo fetal damage: 

            While using this in pregnancy then the drug Tasigna 150mg causes fetal damage Examine the patients properly who are stop the Tasigna 150mg therapy, the range of Bcr-Abl transcripts level. Use the drug with caution while using Tasigna in patient who are suffered with Hypokalemia Hypomagnesemia Hepatotoxicity Electrolyte abnormalities 

Long QT syndrome :

            Monitor ECG frequently Avoid concomitant use of Tasigna 150mg with anti-arrhythmia agents Provide supportive measures 

Pancreatitis and elevated lipase :

            Patient suffering with pancreatitis may have serum lipase levels increase, this may results in abdominal symptoms and to decrease the problems, treatment should be postponed & undergone with appropriate diagnostics. Test serum lipase value periodically.

Tumor lysis syndrome: 

          Maintain with sufficient hydration Balance the level of uric acid before starting the treatment.


DRUG INTERACTION

          While interaction of strong CYP3A inhibitors with tasigna drug interactions leads to increase nilotinib concentrations compared to while using Tasigna 150mg alone Concomitant use with strong CYP3A inducer leads to reduce nilotinib concentration Tasigna 150mg interaction With proton pump inhibitors: decrease the Tasigna efficacy Avoid combination of Tasigna with drugs that may prolong the QT interval like anti-arrhythmic drugs.

CONTRAINDICATION

          Tasigna tablet is contraindicated in the patients who are having; Hypokalemia Hypomagnesemia Long QT syndrome

MISSED DOSE

           If patients missed to have the dose , then administer the dose of Tasigna 150mg should be take within the time, or the missed dose should be swapped and continue the next dosing schedule. Consult with your doctor for more clarification


tasigna 150mg tablet
tasigna 150mg tablet

STORAGE

          Stored at between 68℉ to 77℉ (20℃ to 25℃) room temperature keep away from heat, moisture and light.


SIDE EFFECTS

General:      Fatigue, pyrexia, asthenia, peripheral edema, face edema
Pulmonary: Dyspnae , Cough, oropharyngeal pain,
Skin:            Rash, Pruritus, alopecia, dry skin
GIT:             Nausea, constipation, diarrhea, vomiting, upper abdominal pain, dyspepsia
Nerve system: Dizziness , Headache,
Vascular:         Hypertension
Muscle:           Myalgia, arthralgia, muscle spasm, pain in extremity, back pain
Infections & infestations: Nasopharyngitis, upper respiratory tract infection, influenza,                                                                 gastroenteritis
Eye:                Eyelid edema, periorbital edema
Psychiatric:    Insomnia , this are the tasigna side effects.

Phone Number

+91-9987711567

URL

Email ID
applepharmaceutical@gmail.com
info@myapplepharma.com

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