Zecyte 500mg
Zecyte 500mg is known as fluoropyrimidine carbamat who having the anti-cancer activity. The drug supplied as oblong and film coated tablet for oral administration, the main ingredient which is used as abiraterone .Zecyte 500mg is a systemic prodrug of 5’-deoxy-5-fluorouridine (5’-DFUR) which is changed to 5 fluoro uracilZecyte is also have anti-metabolite activity and the activity of Zecyte tablet will inhibits the growth of tumor cells and slows their spread in the body. Zecyte is prescription drugs sold under the proper guidance of medical oncologist and pharmacist.
MECHANISM OF ACTION
Enzymes changes capecitabine to 5-fluorouracil (5-FU) in vivo. Both normal and cancer cells metabolize 5-FU to 5-fluoro-2’-deoxyuridine monophosphate (FdUMP) and 5-fluorouridine triphosphate (FUTP). These metabolites leads to cell damage by two different mechanisms. First, FdUMP and the folate cofactor, N5-10-methylenetetrahydrofolate, link to thymidylate synthase (TS) and form a complex of covalently bound ternary. This bounding prohibits the thymidylate from 2’-deoxyuridylate formation. Thymidylate is the required precursor of thymidine triphosphate, which is specifically used for the synthesis of DNA, so that a inadequacy of this mixture can prevent cell division. Second, during the synthesis of RNA the nuclear transcriptional enzymes can mistakenly fused FUTP in place of uridine triphosphate (UTP). This metabolic error can prevent RNA processing and synthesis of protein.
Monotherapy:
First line therapy of patients with advanced colorectal cancer:
The usual dose of Zecyte is 1250mg/m2 should be taken orally as twice daily (morning and evening dose 2250MG/m2); therapy continue for 2 weeks followed by 1 week rest period given as 3 weeks cycle
Adjuvant therapy for Duke’s colon cancer:
The usual dose of Zecyte is 1250mg/m2 orally as twice daily (morning and evening dose 2250MG/m2); for 2 weeks followed by 1 week given as 3 weeks for total 8 cycles (24 weeks)
Breast cancer
Monotherapy: Recommended dose: 1250mg/m2 should be taken as orally for twice daily In combination with docetaxel; 1250mg/m2 of Zecyte with 75mg/m2 of docetaxel for 3 weeks After a meal the drug Zecyteshould be given within 30 minutesIn pediatric
The safety and efficacy of the Zecyte 250mg tablets in pediatric patients has not been establishedPHARMACOKINETIC
Absorption: The time to peak plasma level at about 1.5 hours Food reduced both the rate and duration of absorption of Zecyte with mean Cmax and AUC0-∞ reduced by 60% and 35% respectively
Distribution: The human plasma protein bound to Zecyte is occurs in less than 60%
Bio-activation and metabolism:
Zecyte 500mg is largely metabolized to 5-FU enzymatically. In liver, 60 kDa carboxylesterase hydrolyses to 5’-deoxy-5-fluorocytidine. An enzyme which converts 5’-DFCR to 5’-DFUR known as Cytidine deaminase. another an enzyme which involved in the conversion of 5’-DFUR to 5-FU active drug is Thymidine phosphorylase
Excretion:
The route of elimination of Zecyte 500mg is occurred through urine 95.5% The mean terminal half life period of Zecyte is 0.75 hour
Distribution: The human plasma protein bound to Zecyte is occurs in less than 60%
Bio-activation and metabolism:
Zecyte 500mg is largely metabolized to 5-FU enzymatically. In liver, 60 kDa carboxylesterase hydrolyses to 5’-deoxy-5-fluorocytidine. An enzyme which converts 5’-DFCR to 5’-DFUR known as Cytidine deaminase. another an enzyme which involved in the conversion of 5’-DFUR to 5-FU active drug is Thymidine phosphorylase
Excretion:
The route of elimination of Zecyte 500mg is occurred through urine 95.5% The mean terminal half life period of Zecyte is 0.75 hour
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| zecyte 500mg |
PRECAUTION AND WARNING
Cardio toxicity:
while taking Zecyte 500mg, cardio toxicity occurs like; myocardial infarction, angina, dyshythmias, cardiac arrest sudden death, Cardiomyopathy Diarrhea: patients with severe diarrhea should be monitored Dihydropyrimidine dehydrogenase deficiency Dehydration and renal failure Embryo fetal toxicity Mucocutaneous and dermatologic toxicity Hyperbilirubinaemia Hematological problems Care should be taken while using in geriatric patients Hepatic insufficiency Coagulopathy: concomitant with warfarin, anti-coagulant response should be monitored
DRUG INTERACTION
Zecyte 500mg interaction with warfarin and phenprocoumon, bleeding occurs. These events occurred within several days and even a month also Interaction of phenytoin with Zecyte 500mg, toxicity related to elevation of phenytoin levels Concomitant use of Leucovorin: the toxicity and concentration of 5-FU increased by Leucovorin. In elderly patients, phenytoin and Leucovorin is administered weekly which may cause; diarrhea, dehydration, enterocolitis which may causes death. other than warfarin, there is no drug interaction occurs while concomitant with CYP2C9 substrates While combination of Zecyte with CYP2C9 substrates Care should be takenDRUG-FOOD INTERACTION
In case of administering Zecyte 500mg with food, it leads to reduce the rate and duration of absorption of Zecyte.Zecyte 500mg(Abiraterone acetate) tablets should be administered within 30 minutes after food.CONTRAINDICATION
Renal impairment patients.Patients with hypersensitivity to Zecyte or other components.MISSED DOSE
If dose is missed then take the dose of Zecyte 500mg, must consult with medical oncologist and follow the suggestions Avoid taking self medicate. Or missed dose must be skipped and continue the regular dosing schedule Do not double the dose |
| zecyte 500mg tablet |
SIDE EFFECTS
Most common side effects :
Diarrhea, nausea, anemia, Lymphopenia, head and foot syndrome, edema, fatigue, fever, headache, pain, paresthesia, alopecia, dermatitis, abdominal pain, anorexia, loss of appetite, constipation, dyspepsia, stomatitis, vomiting, neutropenia, thrombocytopenia, dyspnea, bilirubin decreased, eye irritation
Common side effects :
Dermatitis , rash, dizziness, headache, Chest pain, weakness, dehydration, dry mouth, dyspepsia, Pruritus, taste disturbance, back pain Post marketing reports: Toxic leukoencephalopathy
PREGNANCY
Pregnancy category:
D Zecyte may cause harm to the fetus. Generally Zecyte should not be recommended in pregnancy or women who are become pregnant
Phone Number
+91-9987711567
URL
Email ID
applepharmaceutical@gmail.com
info@myapplepharma.com
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